Anordrin

基本解释

Anordrin has first been synthesized and developed in China in 1970’s .
双炔失碳酯，是70年代我国自行研制的甾体避孕药物，开始曾试用于抗早孕，随后将它改作探亲避孕药(很多文献将它归为紧急避孕药)。
Objective: To find anordrin analogs possessing higher bioactivity and lower side effect after reconstructing anordrin.
目的:通过改造双炔失碳酯的化学结构,获得活性更高、副作用更小的避孕药。
The relative binding affinities (RBA) of four steroid hormonal drugs for estrogen receptors of uterine cytosol were detemined by competitive binding assay and shown to be in the following order: ethinyl ostradiul>estradiul>anordrin>danazol.
根据[~3H]E_2和E_R具有高度专一性及亲和力的特性,应用竞争性试验比较了炔雌醇(EE)、雌二醇(E_2)、双炔失碳酯(Anordrin)、丹那唑(D)与兔子宫胞液雌激素受体的相对结合亲和力;
BONDED NORMAL PHASE HPLC DETERMINATION OF ANORDRIN
“抗孕-53”差向异构体的键合相正相HPLC分析与熔融温度测定
Keywords Anordrin;Analogue;Antifertility activity;
双炔失碳酯;类似物;抗生育活性;