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Amylin Pharmaceuticals Inc. of San Diego, which bought the rights to leptin from Amgen Inc. in 2006, is testing it, in combination with pramlintide, a diabetes drug. 但在此前研究中，研究對象攝入瘦素替代品後，成功地逆轉了這一新陳代謝變化過程，進而保持了減肥成果。